Scientist - Electrophysiologist

South San Francisco, California

Job ID: 00415510

Who We Are

At the Roche Group, about 80,000 people across 150 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. A member of the Roche Group, Genentech has been at the forefront of the biotechnology industry for more than 30 years, using human genetic information to develop novel medicines for serious and life-threatening diseases. The headquarters for Roche pharmaceutical operations in the United States, Genentech has multiple therapies on the market for cancer and other serious illnesses. Please take this opportunity to learn about Genentech, where we believe that our employees are our most important asset and are dedicated to remaining a great place to work.

The Position

Wehave an opening for a talented electrophysiologist to join our BiochemicalPharmacology group as part of the small molecule drug discovery program in ourSouth San Francisco location. The successful candidate will be responsible for providingsupport for specific projects in theneuroscience and immunology indications using in vitro electrophysiologicaltechniques.  More specifically, theindividual will focus on developing, optimizing and validating protocols forligand and voltage-gated ion channel targets to evaluate the structure-activityrelationships (SAR) and mechanism-of-action of small molecules in the contextof multi-disciplinary project teams.  Inaddition, the individual will be expected to provide scientific guidance to theprosecution of ion channel small molecule targets, including assay development,assay cascades, and counterscreening strategies.  Leadership in employment or development of newtechnologies, including medium throughput electrophysiology equipment, is alsoexpected.  Close collaboration with ourmedicinal chemists, in vivo pharmacologists, and therapeutic area biologyexperts will be essential to success

Who You Are

A Ph.D. and/or post-doctoral training in the electrophysiology of ionchannels , with at least 2 years of industrial experience in generating SAR forsupport of small molecule drug discovery efforts for ion channel targets. Thecandidate should have experience in the development, validation, and executionof protocols for ligand and voltage-gated ion channels.  Experience in designing assay strategies tocapture appropriate leads is critical, as is experience with medium- to high-throughputelectrophysiology equipment and rigorous data analysis methods.  Individuals with strong leadership and communicationskills, and with experience participating in multi-disciplinary project teamsare encouraged to apply.

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Genentech is an Equal Opportunity Employer